Chinese medicine ultrafine pulverization technology
Regarding the ultrafine grinding of traditional Chinese medicine, researchers have given different names and concepts from different research perspectives, such as ultrafine Chinese medicine particles, single-flavored Chinese medicine ultrafine pieces, and ultrafine Chinese medicine powders. Since the effective ingredients of plant medicine and animal medicine are mainly distributed in the cell and intercellular substance, and mainly in the cell, some people refer to the pulverization for the purpose of breaking the cells of Chinese medicinal materials as the “cell-level micro pulverization” of Chinese medicine. The traditional Chinese medicine powder obtained by the micro-grinding method is called “cell-grade Chinese medicine powder”. Similarly, the traditional Chinese medicine prepared on the basis of cell-grade Chinese medicine powder is called “cell-grade Chinese medicine”, or “micro-powder Chinese medicine” for short.
Some people call powders with a particle size greater than 1μm as “fine powder”, and fine powders with a particle size less than 1μm as “ultrafine powder”. In fact, in terms of the particle size of traditional Chinese medicines, micro and nano traditional Chinese medicines that are currently in the ascendant of research are also classified as ultra-micro preparations of traditional Chinese medicines. Lu Fuer et al. believe that “micron Chinese medicine preparations” belong to cell-grade micropowder preparations, which are a new dosage form developed by using modern high-tech and traditional processing and preparation techniques. Generally, the particle size should be 1-75μm. Traditional Chinese medicines within the scope can maintain the inherent pharmacodynamic material basis of traditional Chinese medicines. “Micron Chinese medicine” includes micron Chinese medicinal materials, micron extracts of Chinese medicines, and micron Chinese medicine preparations, which increase the cell wall breakage rate of Chinese medicinal materials by more than 90%. The so-called “nano Chinese medicine” refers to the effective ingredients, effective parts, original medicines, and compound preparations of traditional Chinese medicines with a particle size of less than 100nm manufactured by the application of nanotechnology. It is a kind of Chinese medicine powder after nanometerization. According to the above point of view, some researchers divide the ultrafine powder into micron level (>1μm), submicron level (0.1-1μm) and nano level (1-100nm), and divide the ultrafine powder technology into micron technology. , Submicron technology and nanotechnology.
Judging from the current research progress, although there are many names of Chinese medicine ultrafine grinders, related concepts and connotations are not the same, most of them think that the ultrafine grinding of Chinese medicine refers to the cell-level pulverization of Chinese medicine. The particle size is below 75μm. With the continuous deepening of research work, the definition or concept of ultrafine grinding of traditional Chinese medicine will be more scientific and accurate.
The Chinese medicine ultrafine grinder has a high cell wall breaking rate, which is conducive to the release and absorption of drugs. Ordinary crushed medicinal powder has a low rate of cell wall breaking. When the medicine enters the body, the powder particles of the medicinal powder absorb water and expand, and the active ingredients are continuously released from the cell wall and cell membrane through diffusion. Diffusion requires a concentration difference between the inside and outside of the cell. When the concentration difference between the inside and outside of the cell is small or balanced, the release rate of the active ingredient will be very slow or even stop. The active ingredient located in the inner cell is sometimes excreted before it can be released, so it is often not reached. To an effective therapeutic concentration.
After the Chinese medicine ultrafine grinder, the cell wall breakage rate is high, and the active ingredients are exposed before entering the body. After entering the body, the soluble ingredients are quickly dissolved. Great adhesion and tightly adhere to the mucosa of the inner wall of the gastrointestinal tract, so that the residence time in the gastrointestinal tract is prolonged, the absorption is more sufficient, and the absorption amount will increase. Since most of the cell wall is destroyed during crushing, the effective ingredients do not need to pass through the cell wall and cell membrane release process. In this way, ultrafine pulverization is far superior to ordinary pulverization in terms of drug release speed and release amount. Mineral medicine can reach micrometers even after ultra-fine grinding, which is conducive to the absorption of medicine and the improvement of curative effect.