Application of metal powder materials in the pharmaceutical industry
Solid pharmaceutical preparations account for about 70% to 80% of pharmaceutical products. The dosage forms containing solid pharmaceuticals include powders, granules, capsules, tablets, powder injections, and suspensions, such as the ibuprofen we used to cure the new crown disease Sustained-release capsules, ibuprofen suspensions, Ganmao granules, etc., are actually closely related to powder materials. The production processes involved include crushing, grading, mixing, granulation, etc. Some solid pharmaceutical preparations need to be modified during the preparation process to improve the powder properties, so as to meet the needs of product quality and powder operation. In addition to the above-mentioned solid pharmaceutical preparations which need to be crushed and processed, the preparation of some raw materials also needs to rely on the catalytic reduction of metal powders.
The application of metal powders in medicine also involves different shape control. Among them, spherical powders are mostly prepared by liquid phase and gas phase methods, and flake powders are mostly prepared by solid phase methods. The particle size, purity and mass fraction of trace elements of metal powder play a decisive role in the yield and pass rate of medicine. The development and application of powder preparation technology and metal powder materials are important to the preparation process and preparation quality of the pharmaceutical industry. influences.
In traditional Chinese medicine preparations and synthetic medicines, traditional Chinese medicine biological powder materials and metal powders have been widely used. At present, for mineral medicines, precious medicines and traditional Chinese medicines with special properties, hammering and ball milling methods are generally used in China. Make the drug reach a certain particle size, and can maintain the inherent pharmacodynamic basic substance of traditional Chinese medicine.
The particle size, quality difference, mixing uniformity, and tablet strength of traditional Chinese medicine are mostly related to the powder. For the medicinal materials processed by ultrafine powder technology, the fluidity, filling and compression molding properties of the solid preparation can be controlled. To achieve the purpose of controlling the quality of solid preparations, and its disintegration, dissolution and bioavailability are related to the powder properties of each material in the drug prescription.
The smaller the particle size of the powder material for traditional Chinese medicine, the better. The powder material of traditional Chinese medicine with a median particle size of about 15 μm has a high cell wall breaking rate, which is beneficial to the release and absorption of the drug; During the process, the homogenization of each active ingredient is conducive to retaining biologically active ingredients and improving the efficacy of the drug; it is easy to shape and apply, which is conducive to exerting the efficacy of the drug and improving the utilization rate of the drug.
When synthesizing western medicine, metal powder materials with a median particle size of about 75 μm are generally used for chemical reactions such as catalysis, reduction and oxidation. In recent years, with the current upsurge of modernization of Chinese and Western medicine and the development of nanotechnology, powder technology also has a broader development space, which provides new methods and approaches for the research of modern drug delivery systems, and also significantly improves the human body’s ability to respond to various diseases. Components Absorption rate and absorption capacity of active ingredients.
As an important industry in the field of fine chemicals, medicine has become the focus of development and competition in the past ten years. The synthesis of modern medicine depends on the production of new and high-quality pharmaceutical intermediates, so more and more people pay attention to powder technology and powder materials; Put forward higher and newer requirements. Among metal powder materials, zinc powder is most widely used in medicine because of its preparation process, physical and chemical properties, good catalytic reduction effect on pharmaceutical intermediates or synthetic drugs, and high product yield. With the increasing safety and environmental protection requirements, powder technology and powder materials will continue to develop, and the development of new alternative technologies and materials has always been promoting the continuous progress of the pharmaceutical industry.